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Health, Safety & Environment

Biotin sulfoxide reductase

Vibrational modes associated with a terminal oxo ligand and the two molybdopterin dithiolene ligands have been assigned. The enzyme cycles between mono-oxo- Mo(VI) and des-oxo-Mo(IV) forms with both molybdopterin dithiolene ligands remaining co-ordinated. In both redox states the terminal oxo group at the molybdenum centre is exchangeable with water during redox cycling and originates from the substrate in substrate-oxidized samples. Product-induced changes in the Mo=O stretching frequency provide direct evidence for a product-associated mono-oxo-Mo(VI) catalytic intermediate.

Garton, S.D., Temple, C. A., Dhawan, I. K., Barber, M. J., Rajagopalan, K. V., and Johnson, M. K., Resonance Raman characterization of biotin sulfoxide reductase - Comparing oxomolybdenum enzymes in the Me2SO reductase family, Journal of Biological Chemistry, 2000, 275, 6798-6805.

Users of the Database should be aware that inclusion of an abstract in the Database does not imply any IMOA endorsement of the accuracy or reliability of the reported data or the quality of a publication.